The "Labradoodle" is a popular "designer dog" that is a cross-bred Labrador and Poodle. Originating in Australia, the intent of breeding this cross was to try and create a service dog suitable for allergy sufferers. However the current fashionability of labradoodles has resulted in indiscriminate breeding, and there is no guarantee such a cross will inherit the hypo-allergenic poodle coat.
Some assistant-dog groups use Golden Retriever / Labrador Retriever hybrids (unofficially called a Golden Labrador Retriever) because they believe this cross produces dogs with a excellent temperaments. However, such crossbreeds are not immune to many of the problems suffered by purebreds, as Golden Retrievers and Labradors have similar health problems.
The assistance dog organization Mira utilises Labrador-Bernese Mountain Dog crosses ("Labernese") with success.