- Jennifer Garner as SD-6/CIA Agent Sydney A. Bristow
- Michael Vartan as CIA Agent Michael Vaughn
- Ron Rifkin as SD-6 Director Arvin Sloane
- Bradley Cooper as Will Tippin
- Merrin Dungey as Francine 'Francie' Calfo
- Melissa George as National Security Council agent Lauren Reed
- Carl Lumbly as SD-6 Agent Marcus R. Dixon
- Lena Olin as Laura Bristow/Irina Derevko
- Kevin Weisman as SD-6 Agent/Ops Tech Marshall Flinkman
- Victor Garber as SD-6/CIA Agent Jack D. Bristow
- Ilodie Bouchez as Renie Rienne
- Rachel Nichols as Rachel Gibson
- Balthazar Getty as Thomas Grace
|