Kimberly McCullough ... Dr. Robin Scorpio (27 episodes, 2007-2008)
Jason Thompson ... Dr. Patrick Drake / ... (27 episodes, 2007-2008)
Sonya Eddy ... Epiphany Johnson / ... (25 episodes, 2007-2008)
Billy Dee Williams ... Touissant DuBois / ... (25 episodes, 2007-2008)
Richard Gant ... Dr. Russell Ford / ... (14 episodes, 2007-2008)
Azita Ghanizada ... Dr. Saira Batra (14 episodes, 2008)
Adam Grimes ... Dr. Kyle Julian (14 episodes, 2008)
Ethan Rains ... Dr. Leo Julian / ... (14 episodes, 2008)
Antonio Sabato Jr. ... Jagger Cates (14 episodes, 2008)
Carrie Southworth ... Dr. Claire Simpson (14 episodes, 2008)
Steve Burton ... Jason Morgan (13 episodes, 2007)
Bradford Anderson ... Damien Spinelli (13 episodes, 2007)
Amanda Baker ... Jolene Crowell (13 episodes, 2007)
Nazanin Boniadi ... Leyla Mir (13 episodes, 2007)
Kent King ... Dr.Lainey Winters / ... (13 episodes, 2007)
Minae Noji ... Kelly Lee / ... (13 episodes, 2007)
Dominic Rains ... Dr. Leo Julian (13 episodes, 2007)
Angel M. Wainwright ... Regina Thompson (13 episodes, 2007)
Ron Melendez ... Dr. Andy Archer (13 episodes, 2007)
Graham Shiels ... Cody Paul (13 episodes, 2007)
Hadeel Sittu ... Barrett (13 episodes, 2007)
Tristan Rogers ... Robert Scorpio (12 episodes, 2008)
David M. Tran ... Orderly (9 episodes, 2007)
Wendy Braun ... Ms. Iris Sneed (8 episodes, 2007)
Erica Ellis ... Heather (7 episodes, 2007)
Cameron Boyce ... Michael 'Stone' Cates Jr. / ... (7 episodes, 2008)
John J. York ... Malcolm 'Mac' Scorpio / ... (6 episodes, 2007-2008)
James Harper ... Jordan Lovell (6 episodes, 2007)
Kirsten Storms ... Maxie Jones (5 episodes, 2007)
Alla Korot ... Stacy Sloan / ... (5 episodes, 2007)
Chad Allen ... Eric Whitlow (5 episodes, 2008)
Oscar Arana ... Doctor (4 episodes, 2007)
Rick Fitts ... Roger Winters (4 episodes, 2007)
Marilyn McIntyre ... Lori Thompson (4 episodes, 2007)
Finola Hughes ... Anna Devane (4 episodes, 2008)
Kiko Ellsworth ... Stan Johnson / ... (3 episodes, 2007)
Rebecca Herbst ... Elizabeth Spencer / ... (3 episodes, 2007)
Nathan Anderson ... Curtis Reitzel (3 episodes, 2007)
Danny Arroyo ... Pablo Garcia (3 episodes, 2007)
Pat Crawford Brown ... Mrs. Storch (3 episodes, 2007)
Chrissie Fit ... Lupe Rosales (3 episodes, 2007)
Edwin Gonzalez ... Javy (3 episodes, 2007)
Ray Proscia ... Sanders / ... (3 episodes, 2007)
Jae Toyota ... Nurse (3 episodes, 2007)
Laura Lyman ... Anesthesiologist / ... (3 episodes, 2008)
David Pearl ... Doctor (3 episodes, 2008)
Wendy Louise Pennington ... Sophia (2 episodes, 2007-2008)
Patrick Viall ... Intern #1 / ... (2 episodes, 2007-2008)
Adrian Alvarado ... Detective Cruz Rodriguez (2 episodes, 2007)
Jesse C. Boyd ... Jared Moore (2 episodes, 2007)
Molly Cheek ... Marion Moore (2 episodes, 2007)
Christopher Curry ... Jared's Father (2 episodes, 2007)
Jason Gerhardt ... Coop Barrett / ... (2 episodes, 2007)
Reign Morton ... Young Toussaint (2 episodes, 2007)
Alan Bovinett ... Doctor (2 episodes, 2008)
Leslie Charleson ... Dr. Monica Quartermaine (2 episodes, 2008)
Anthony Geary ... Luke Spencer (2 episodes, 2008)
Sean Hampton ... Orderly (2 episodes, 2008)
Heather Hudson ... Intern (2 episodes, 2008)
John Reilly ... Sean Donely (2 episodes, 2008)
Toni Sawyer ... Mrs. Whitlow (2 episodes, 2008)
Joshua Snyder ... Ryan McCormick (2 episodes, 2008)
Sharon Wyatt ... Tiffany Hill Donely (2 episodes, 2008)
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